NRL News

Skin Cells Become Beating Heart Tissue

by | May 23, 2012

By Wesley J. Smith

Good ethics and good science are an unbeatable combination.  For example, I believe that in part due to President Bush’s keeping the focus on the value of human embryonic life, scientists looked for ways to get the hoped for benefits of embryonic stem cells, without destroying or cloning embryos. This led to the induced pluripotent stem cell breakthrough that takes normal cells, changes them to stem cells, and thence into other types of tissue. Now, an important IPSC study has shown that skin cells made into cardiac cells function well in the heart. From the FNN story:

In the first procedure of its kind, skin cells taken from patients suffering from heart failure were “reprogrammed” and changed into heart muscle cells. Not only were the transformed cells healthy, but they were also  transplanted into the hearts of rats and were able to integrate with the  existing heart tissue. Published in the European Heart Journal, the research examined the use of human-induced pluripotent stem cells (hiPSCs) to treat damaged hearts.   HiPSCs are cells that are derived from other cells in a person’s body.

“We were able to show [in earlier studies] that you can take these hiPSCS  from healthy heart patients and coax them into bonafide heart cells,” lead  author Lior Gepstein, professor of medicine (cardiology) and physiology at the  Technion-Israel Institute of Technology and Rambam Medical Center in Haifa,  Israel, told  “The question we asked in this study was whether  you can do the same from an elderly individual that had suffered from advance heart failure.” Because hiPSCs are derived from the person in need of the stem cells, they could potentially help to bypass the painful process of rejection that many  transplant patients go through.  According to Gepstein, if this process is  perfected, it could lead to much more localized treatments…

And that could materially impact health care costs, if it works.

At this point, it is important to remember that any time you deal with pluripotent stem cells, tumors are a potential problem. And let us be clear: This isn’t near ready for the clinical setting, but rather, is an “important incremental step,” as a scientist quoted in the story notes.  But that’s how science progresses; step, by step, by step. …

Editor’s note. This appeared on Wesley’s great blog.

Categories: Adult Stem Cells